Transcriptional Intermediary Factor 1 Beta (TIF1b)

TRIM28; KAP1; RNF96; TF1B; Tripartite Motif Containing 28; E3 SUMO-protein ligase TRIM28; KRAB-associated protein 1; RING finger protein 96; Nuclear corepressor KAP-1

SPN	R746
HGNC	16384
MGI	109274
PubMed	19321449
RGD	620289
UniProt	Q13263

Tripartite motif-containing 28 mediates transcriptional control by interaction with the Krüppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions.

The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region.Forms a complex with a KRAB-domain transcription factor and increases the efficiency of KRAB-mediated repression. Silences transcription through an interaction with HP1 proteins. Acts as a corepressor of transcription for the KRAB zinc finger proteins and as a moderator of the repression activity.

Reference

"KAP-1, a novel corepressor for the highly conserved KRAB repression domain."
Genes Dev. 10:2067-2078(1996) [PubMed] [Europe PMC] [Abstract]

"Transcriptional repression by RING finger protein TIF1 beta that interacts with the KRAB repressor domain of KOX1."
Nucleic Acids Res. 24:4859-4867(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAY-2006) to UniProtKB