G Protein Beta 2 (GNb2)

Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T)Beta Subunit 2; Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta Subunit; Transducin Beta Chain 2

SPN	R730
HGNC	4398
MGI	95784
PubMed	22314363
RGD	69319
UniProt	P62879
Wiki	GNB2

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction.
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. GNb2 is a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR.

Reference

"Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning."
Proc. Natl. Acad. Sci. U.S.A. 84:3792-3796(1987) [PubMed] [Europe PMC] [Abstract]

"A second form of the beta subunit of signal-transducing G proteins."
Proc. Natl. Acad. Sci. U.S.A. 84:6122-6125(1987) [PubMed] [Europe PMC] [Abstract]

"Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes."
Genome Res. 8:1060-1073(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]