Profilin 4 (PFN4)

SPN	R727
HGNC	31103
MGI	1920121
RGD	1359707
UniProt	Q8NHR9
Wiki	Profilin

Profilin is an actin-binding protein involved in the dynamic turnover and restructuring of the actin cytoskeleton. Profilin is important for spatially and temporally controlled growth of actin microfilaments, which is an essential process in cellular locomotion and cell shape changes. This restructuring of the actin cytoskeleton is essential for processes such as organ development, wound healing, and the hunting down of infectious intruders by cells of the immune system.

Profilin also binds sequences rich in the amino acid proline in diverse proteins. While most profilin in the cell is bound to actin, profilins have over 50 different binding partners. Many of those are related to actin regulation, but profilin also seems to be involved in activities in the nucleus such as mRNA splicing.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation."
Mol. Hum. Reprod. 11:53-64(2005) [PubMed] [Europe PMC] [Abstract]

"Testis-expressed profilins 3 and 4 show distinct functional characteristics and localize in the acroplaxome-manchette complex in spermatids."
BMC Cell Biol. 10:34-34(2009) [PubMed] [Europe PMC] [Abstract]