Nuclear Receptor Corepressor 1 (NCOR1)

KIAA1047; N-CoR; TRAC1; hN-CoR; Thyroid Hormone And Retinoic Acid Receptor Associated Corepressor 1

SPN	R702
HGNC	7672
MGI	1349717
PubMed	23610395
RGD	3612
UniProt	O75376
Wiki	NCOR1

nuclear receptor co-repressor 1 (NCOR1) appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.

NCOR1is a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

Reference

"ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex."
Proc. Natl. Acad. Sci. U.S.A. 95:10860-10865(1998) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 6:197-205(1999) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Localization of the human nuclear receptor co-repressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2."
Genomics 59:339-341(1999) [PubMed] [Europe PMC] [Abstract]

"Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development."
Mol. Endocrinol. 11:1737-1746(1997) [PubMed] [Europe PMC] [Abstract]

"A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1."
J. Biol. Chem. 275:40463-40470(2000) [PubMed] [Europe PMC] [Abstract]

"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Mol. Cell. Biol. 21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]

"The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
Mol. Cell 9:611-623(2002) [PubMed] [Europe PMC] [Abstract]

"The histone deacetylase 9 gene encodes multiple protein isoforms."
J. Biol. Chem. 278:16059-16072(2003) [PubMed] [Europe PMC] [Abstract]

"DACH1 inhibits transforming growth factor-beta signaling through binding Smad4."
J. Biol. Chem. 278:51673-51684(2003) [PubMed] [Europe PMC] [Abstract]

"N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso."
Mol. Cell 12:723-734(2003) [PubMed] [Europe PMC] [Abstract]

"MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation."
Cell 119:75-86(2004) [PubMed] [Europe PMC] [Abstract]

"JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2)."
Mol. Cell. Biol. 25:6404-6414(2005) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"Regulation of P-TEFb elongation complex activity by CDK9 acetylation."
Mol. Cell. Biol. 27:4641-4651(2007) [PubMed] [Europe PMC] [Abstract]

"Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes."
Mol. Endocrinol. 21:1791-1806(2007) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters."
Cell Rep. 4:578-588(2013) [PubMed] [Europe PMC] [Abstract]

"Structural and functional analysis of the DEAF-1 and BS69 MYND domains."
PLoS ONE 8:E54715-E54715(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the first SANT domain from human nuclear receptor corepressor 1."
Submitted (APR-2008) to the PDB data bank

"A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor."
Nat. Struct. Mol. Biol. 17:801-807(2010) [PubMed] [Europe PMC] [Abstract]