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Ubiquitin Specific Peptidase 2 (USP2)

UBP41; Ubiquitin carboxyl-terminal hydrolase 2; Ubiquitin Specific Protease 2; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2

Ubiquitin, a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).
Using a double-screening method of bacteria expressing chick skeletal muscle cDNA, Baek et al. (1997) isolated a cDNA encoding a deduced 357-amino acid protein expressing deubiquitinating activity. Because SDS-PAGE analysis indicated a 41-kD purified protein, the authors termed the protein Ubp41. The International Radiation Hybrid Mapping Consortium mapped the USP2 gene to chromosome 11.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins R661Hu01 Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins R661Mu01 Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Ubiquitin Specific Peptidase 2 (USP2) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Ubiquitin Specific Peptidase 2 (USP2) Bioactivity
Antibodies NONE Monoclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Ubiquitin Specific Peptidase 2 (USP2) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Ubiquitin Specific Peptidase 2 (USP2) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Ubiquitin Specific Peptidase 2 (USP2) CLIA assay for Antigen Detection

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2."
EMBO J. 26:976-986(2007) [PubMed] [Europe PMC] [Abstract]

"Suppression of cancer cell growth by promoting cyclin D1 degradation."
Mol. Cell 36:469-476(2009) [PubMed] [Europe PMC] [Abstract]

"MdmX is a substrate for the deubiquitinating enzyme USP2a."
Oncogene 29:432-441(2010) [PubMed] [Europe PMC] [Abstract]

"Expression of USP2-69 in mesangial cells in vivo and in vitro."
Pathol. Int. 60:184-192(2010) [PubMed] [Europe PMC] [Abstract]

"Covalent ubiquitin-usp2 complex."
Submitted (FEB-2009) to the PDB data bank

"Structural basis of ubiquitin recognition by the deubiquitinating protease USP2."
Structure 14:1293-1302(2006) [PubMed] [Europe PMC] [Abstract]