Exportin 4 (XPO4)

Exp4

SPN	R642
HGNC	17796
MGI	1888526
PubMed	10944119
RGD	1312015
UniProt	Q9C0E2

XPO4 belongs to a large family of karyopherins that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments.

The 3-prime UTR contains a repetitive sequence, and the 1,150-amino acid protein shares 99% amino acid identity with mouse Xpo4. RT-PCR ELISA detected high to moderate expression in all human tissues and specific brain regions examined. human XPO4 interacted with Smad3 via the Smad3 MH2 domain. RNAi knockdown of XPO4 blocked Smad3 export, as did addition of competing short peptides representing the Smad3-XPO4 interaction domain. In vivo and in vitro assays showed that XPO4 mediated nuclear export of Smad3 in a RanGTPase-dependent manner.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Hu01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Hu01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Hu01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Hu01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Hu01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Mu01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Mu01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Mu01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Mu01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Mu01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Ra01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Ra01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Ra01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Ra01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Ra01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Ca01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Ca01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Ca01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Ca01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Ca01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Po01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Po01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Po01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Po01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Po01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Bo01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Bo01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Bo01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Bo01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Bo01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Rb01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Rb01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Rb01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Rb01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Rb01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR642Mo01	Recombinant Exportin 4 (XPO4)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR642Mo01	Monoclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IP.
Antibodies	PAR642Mo01	Polyclonal Antibody to Exportin 4 (XPO4)	WB; IHC; ICC; IF.
Assay Kits	CLR642Mo01	CLIA Kit for Exportin 4 (XPO4)	CLIA assay for Antigen Detection
Assay Kits	ELR642Mo01	ELISA Kit for Exportin 4 (XPO4)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes."
EMBO J. 19:4362-4371(2000) [PubMed] [Europe PMC] [Abstract]

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

"The mechanism of nuclear export of Smad3 involves exportin 4 and Ran."
Mol. Cell. Biol. 26:1318-1332(2006) [PubMed] [Europe PMC] [Abstract]

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