Tight Junction Protein 3 (TJP3)

ZO-3; Zona Occludens 3; Zonula occludens protein 3

SPN	R635
HGNC	11829
MGI	1351650
PubMed	18275946
RGD	1309247
UniProt	O95049
Wiki	TJP3

TJP3 is a member of the family of membrane-associated guanylate kinase-like proteins (MAGUK) that associate with intracellular junctions.Using a peptide sequence derived from a 130-kD protein that coimmunoprecipitated with TJP1 in canine kidney cells, Haskins et al. (1998) isolated canine Tjp3, which they called ZO3. The deduced 898-amino acid protein has a predicted molecular mass of 98 kD, although it runs anomalously at 130 kD by SDS PAGE. Canine Tjp3 shares 47% amino acid identity with human TJP1 and TJP2. The Tjp3 protein contains 3 PDZ domains, an SH3 domain, and a guanylate kinase (GUK) domain with high similarity to TJP1 and TJP2, as well as a unique proline-rich region between PDZ2 and PDZ3. Immunogold electro microscopy localized TJP3 with TJP1 to tight junctions in canine kidney cells.

Reference

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."
BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]

"Characterization of the ubinuclein protein as a new member of the nuclear and adhesion complex components (NACos)."
Biol. Cell 101:319-334(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the SH3-kinase fragment of tight junction protein 3 (TJP3) in apo-form."
Submitted (NOV-2009) to the PDB data bank