17-Beta-Hydroxysteroid Dehydrogenase Type 1 (HSD17b1)

EDH17B2; EDHB17; HSD17; SDR28C1; Estradiol 17-Beta-Dehydrogenase 1; Short Chain Dehydrogenase/Reductase Family 28CE,1; 20 alpha-hydroxysteroid dehydrogenase

SPN	R631
HGNC	5210
MGI	105077
PubMed	16311626
RGD	2836
UniProt	P14061
Wiki	HSD17B1

HSD17B mRNA expression was studied by RT-PCR in 42 pituitary tumors and 3 normal pituitaries, HSD17B activity was studied in 11 tumors, and HSD17B1 was immunolocalized in vitro in 6 tumors. HSD17B1 gene expression was detected in 34 of 42 (81%) adenomas in all tumor subtypes; HSD17B2 mRNA was detected in 18 of 42 (43%) adenomas but not in prolactinomas; HSD17B3 mRNA was detected in 12 of 42 (29%) adenomas but not in corticotropinomas; and HSD17B4 was expressed in 20 of 42 (48%) adenomas by all adenoma subtypes. All 4 HSD17B isoforms were variably expressed in human anterior pituitary adenomas, which also showed HSD17B enzyme activity, suggesting that HSD17B may play an important role in regulating the local cellular levels of estradiol.

Reference

"Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA."
FEBS Lett. 239:73-77(1988) [PubMed] [Europe PMC] [Abstract]

"Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta."
Mol. Endocrinol. 3:1301-1309(1989) [PubMed] [Europe PMC] [Abstract]

"Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes."
Mol. Endocrinol. 4:268-275(1990) [PubMed] [Europe PMC] [Abstract]

"Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase."
Ann. N. Y. Acad. Sci. 595:40-52(1990) [PubMed] [Europe PMC] [Abstract]

"Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements."
Eur. J. Biochem. 209:459-466(1992) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Amino acid composition and subunit structure. Human placental 17 - estradiol dehydrogenase."
Biochemistry 11:2699-2703(1972) [PubMed] [Europe PMC] [Abstract]

"Human placental 17 -oestradiol dehydrogenase. Sequence of a tryptic peptide containing an essential cysteine."
FEBS Lett. 29:173-176(1973) [PubMed] [Europe PMC] [Abstract]

"Human placental estradiol 17 beta-dehydrogenase: sequence of a histidine-bearing peptide in the catalytic region."
Biochemistry 25:641-646(1986) [PubMed] [Europe PMC] [Abstract]

"Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione."
J. Biol. Chem. 258:11460-11464(1983) [PubMed] [Europe PMC] [Abstract]

"Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti."
Mol. Endocrinol. 3:881-884(1989) [PubMed] [Europe PMC] [Abstract]

"Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20-A resolution."
Structure 3:503-513(1995) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol."
Nat. Struct. Biol. 3:665-668(1996) [PubMed] [Europe PMC] [Abstract]

"The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors."
Structure 4:905-915(1996) [PubMed] [Europe PMC] [Abstract]

"Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase."
J. Biol. Chem. 273:8145-8152(1998) [PubMed] [Europe PMC] [Abstract]

"Structure of the ternary complex of human 17beta-hydroxysteroid dehydrogenase type 1 with 3-hydroxyestra-1,3,5,7-tetraen-17-one (equilin) and NADP+."
Proc. Natl. Acad. Sci. U.S.A. 96:840-845(1999) [PubMed] [Europe PMC] [Abstract]

"Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain."
J. Biol. Chem. 275:1105-1111(2000) [PubMed] [Europe PMC] [Abstract]

"A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity."
FASEB J. 16:1829-1831(2002) [PubMed] [Europe PMC] [Abstract]

"Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase."
FASEB J. 17:274-276(2003) [PubMed] [Europe PMC] [Abstract]

"Cofactor hydrogen bonding onto the protein main chain is conserved in the short chain dehydrogenase/reductase family and contributes to nicotinamide orientation."
J. Biol. Chem. 279:16778-16785(2004) [PubMed] [Europe PMC] [Abstract]

"Detection of polymorphisms in the estradiol 17 beta-hydroxysteroid dehydrogenase II gene at the EDH17B2 locus on 17q11-q21."
Hum. Mol. Genet. 2:479-483(1993) [PubMed] [Europe PMC] [Abstract]