Bcl2 Associated Athanogene 4 (BAG4)
SODD; Silencer Of Death Domains; BAG family molecular chaperone regulator 4
BAG4 encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Hu01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Hu01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Hu01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Hu01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Hu01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Mu01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Mu01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Mu01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Mu01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Mu01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Ra01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Ra01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Ra01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Ra01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Ra01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Ca01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Ca01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Ca01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Ca01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Ca01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Po01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Po01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Po01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Po01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Po01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Bo01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Bo01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Bo01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Bo01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Bo01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Rb01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Rb01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Rb01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Rb01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Rb01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR575Mo01 | Recombinant Bcl2 Associated Athanogene 4 (BAG4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR575Mo01 | Monoclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IP. |
| PAR575Mo01 | Polyclonal Antibody to Bcl2 Associated Athanogene 4 (BAG4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR575Mo01 | CLIA Kit for Bcl2 Associated Athanogene 4 (BAG4) | CLIA assay for Antigen Detection |
| ELR575Mo01 | ELISA Kit for Bcl2 Associated Athanogene 4 (BAG4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators."
J. Biol. Chem. 274:781-786(1999) [PubMed] [Europe PMC] [Abstract]
"Prevention of constitutive TNF receptor 1 signaling by silencer of death domains."
Science 283:543-546(1999) [PubMed] [Europe PMC] [Abstract]
Erratum
Science 283:1852-1852(1999)
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"BAG4/SODD protein contains a short BAG domain."
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