Calcium Channel, Voltage Dependent, N-Type, Alpha 1B Subunit (CACNa1B)

CACNN; CACNL1A5; BIII; Brain calcium channel III; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2

SPN	R561
HGNC	1389
MGI	88296
PubMed	21166801
RGD	628852
UniProt	Q00975
Wiki	CACNA1B

Voltage-dependent Ca(2+) channels are multisubunit complexes found in the membrane of many excitable cells that regulate calcium entry. N-type calcium channels, which control neurotransmitter release from neurons, are dihydropyridine-insensitive and omega-conotoxin-sensitive.

CACNA1B form a macromolecular complex. Functional studies in Xenopus oocytes indicated that expression of ENH resulted in increased rapid and specific modulation of N-type calcium channels by PKCE. The authors concluded that through interactions with a common adaptor protein, the formation of a kinase-substrate complex is the molecular basis for the specificity and efficiency of cellular signaling.

Reference

"Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel."
Science 257:389-395(1992) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the 5'-upstream region of the human N-type calcium channel alpha1B subunit gene. Chromosomal localization and promoter analysis."
J. Biol. Chem. 272:5098-5104(1997) [PubMed] [Europe PMC] [Abstract]