Cancer Susceptibility Candidate 1 (CASC1)

LAS1; Cancer susceptibility candidate gene 1 protein; Lung adenoma susceptibility 1-like protein

SPN	R540
HGNC	29599
MGI	2444480
PubMed	16862160
RGD	1311213
UniProt	Q6TDU7

This sesquiterpene cyclase, termed as CASC2 showing 77% amino acid identity with the previously cloned sesquiterpene cyclase CASC1, was composed of 560 amino acids with a calculated molecular mass of 64,907. The mRNA expression pattern of CASC2 was very similar to that of CASC1 during the time course of UV-C irradiated leaves of pepper on RNA blot analysis by using each specific probe.

The heterologous expression in Escherichia coli using the CASC2 full length failed; however the chimeric construct of CASC2 in which the amino terminal 164 amino acid substituted by the equivalent portion of either CASC1 or tobacco sesquiterpene cyclase was capable of expressing the functional sesquiterpene cyclase activities.

Reference

"Positional cloning of the major quantitative trait locus underlying lung tumor susceptibility in mice."
Proc. Natl. Acad. Sci. U.S.A. 100:12642-12647(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A V141L polymorphism of the human LRMP gene is associated with survival of lung cancer patients."
Carcinogenesis 27:1386-1390(2006) [PubMed] [Europe PMC] [Abstract]