Choline Kinase Beta (CHKb)

CHETK; CHKL; CKEKB; Choline Kinase Like; choline/ethanolamine kinase beta

SPN	R513
HGNC	1938
MGI	1328313
PubMed	18820697
RGD	61826
UniProt	Q9Y259
Wiki	CHKB

Choline kinase beta is a protein found on chromosome 22 in humans.Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine.

This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R513Mu01	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Choline Kinase Beta (CHKb)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Choline Kinase Beta (CHKb)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Choline Kinase Beta (CHKb)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Choline Kinase Beta (CHKb)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Choline Kinase Beta (CHKb)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Choline Kinase Beta (CHKb)	CLIA assay for Antigen Detection

Reference

"Novel expression of equivocal messages containing both regions of choline/ethanolamine kinase and muscle type carnitine palmitoyltransferase I."
J. Biol. Chem. 275:31739-31746(2000) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 22."
Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

, Submitted (MAY-2006) to UniProtKB

"Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment."
PLoS ONE 4:E7819-E7819(2009) [PubMed] [Europe PMC] [Abstract]

"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide."
Submitted (SEP-2009) to the PDB data bank