Claudin 11 (CLDN11)

Claudin-11 belongs to the claudin family of tight junction associated proteins and is a major component of central nervous system myelin that is necessary for normal CNS function. There is growing evidence that the protein determines the permeability between layers of myelin sheaths via focal adhesion and, with its expression highly regulated during development, may play an important role in cellular proliferation and migration. In addition, the protein is a candidate autoantigen in the development of autoimmune demyelinating disease.Its nucleotide sequence shares little homology with previously reported genes, but the predicted amino acid sequence and structure of the gene product suggest that the protein, which they symbolized Osp, is the central nervous system (CNS) homolog of peripheral myelin protein-22.