Cytokine Receptor Like Factor 1 (CRLF1)

CISS; CISS1; CLF; CLF-1; NR6; Cytokine-like factor 1; ZcytoR5

SPN	R495
HGNC	2364
MGI	1340030
PubMed	21326283
RGD	1311371
UniProt	O75462
Wiki	CRLF1

CRLF1 encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome.

Forms covalently linked di- and tetramers. Forms a heteromeric complex with cardiotrophin-like cytokine (CLC); the CRLF1/CLC complex is a ligand for the ciliary neurotrophic factor receptor (CNTFR). Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung.

Reference

"Cytokine-like factor-1, a novel soluble protein, shares homology with members of the cytokine type I receptor family."
J. Immunol. 161:1371-1379(1998) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"CLF associates with CLC to form a functional heteromeric ligand for the CNTF receptor complex."
Nat. Neurosci. 3:867-872(2000) [PubMed] [Europe PMC] [Abstract]

"Cold-induced sweating syndrome is caused by mutations in the CRLF1 gene."
Am. J. Hum. Genet. 72:375-383(2003) [PubMed] [Europe PMC] [Abstract]

"Cold-induced sweating syndrome: a report of two cases and demonstration of genetic heterogeneity."
J. Neurol. Sci. 250:62-70(2006) [PubMed] [Europe PMC] [Abstract]

"Mutations in cytokine receptor-like factor 1 (CRLF1) account for both Crisponi and cold-induced sweating syndromes."
Am. J. Hum. Genet. 80:966-970(2007) [PubMed] [Europe PMC] [Abstract]

"Crisponi syndrome is caused by mutations in the CRLF1 gene and is allelic to cold-induced sweating syndrome type 1."
Am. J. Hum. Genet. 80:971-981(2007) [PubMed] [Europe PMC] [Abstract]

"Differential secretion of the mutated protein is a major component affecting phenotypic severity in CRLF1-associated disorders."
Eur. J. Hum. Genet. 19:525-533(2011) [PubMed] [Europe PMC] [Abstract]

"Multiple small hyperintense lesions in the subcortical white matter on cranial MR images in two Turkish brothers with cold-induced sweating syndrome caused by a novel missense mutation in the CRLF1 gene."
Brain Dev. 35:596-601(2013) [PubMed] [Europe PMC] [Abstract]

"Expanding the mutational spectrum of CRLF1 in Crisponi/CISS1 syndrome."
Hum. Mutat. 35:424-433(2014) [PubMed] [Europe PMC] [Abstract]