Carboxypeptidase A4 (CPA4)

SPN	R481
HGNC	15740
MGI	1919041
PubMed	10383164
RGD	1563619
UniProt	Q9UI42
Wiki	CPA4

Carboxypeptidase A4 is a member of the carboxypeptidase A/B subfamily, and it is located in a cluster with three other family members on chromosome 7. Carboxypeptidases are zinc-containing exopeptidases that catalyze the release of carboxy-terminal amino acids, and are synthesized as zymogens that are activated by proteolytic cleavage. This gene could be involved in the histone hyperacetylation pathway. It is imprinted and may be a strong candidate gene for prostate cancer aggressiveness. The deduced 421-amino acid CPA4 protein contains 2 zinc-binding signature domains of metallocarboxypeptidases and a 16-amino acid N-terminal signal peptide. The protein shares 63% and 61% sequence identity with human and rat CPA2, respectively.

Reference

"Carboxypeptidase A3 (CPA3): a novel gene highly induced by histone deacetylase inhibitors during differentiation of prostate epithelial cancer cells."
Cancer Res. 59:2981-2988(1999) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The novel imprinted carboxypeptidase A4 gene (CPA4) in the 7q32 imprinting domain."
Hum. Genet. 112:220-226(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of the substrate specificity of human carboxypeptidase A4 and implications for a role in extracellular peptide processing."
J. Biol. Chem. 285:18385-18396(2010) [PubMed] [Europe PMC] [Abstract]

"Detailed molecular comparison between the inhibition mode of A/B-type carboxypeptidases in the zymogen state and by the endogenous inhibitor latexin."
Cell. Mol. Life Sci. 62:1996-2014(2005) [PubMed] [Europe PMC] [Abstract]

"Structure of human carboxypeptidase A4 with its endogenous protein inhibitor, latexin."
Proc. Natl. Acad. Sci. U.S.A. 102:3978-3983(2005) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of novel metallocarboxypeptidase inhibitor from marine mollusk Nerita versicolor in complex with human carboxypeptidase A4."
J. Biol. Chem. 287:9250-9258(2012) [PubMed] [Europe PMC] [Abstract]