Carboxypeptidase B1, Tissue (CPB1)

CPB; PCPB; PASP; Pancreas-specific protein

SPN	R478
HGNC	2299
MGI	1923953
PubMed	23569111
RGD	2391
UniProt	P15086
Wiki	CPB

Three different procarboxypeptidases A and two different procarboxypeptidases B have been isolated. The B1 and B2 forms differ from each other mainly in isoelectric point. Carboxypeptidase B1 is a highly tissue-specific protein and is a useful serum marker for acute pancreatitis and dysfunction of pancreatic transplants. It is not elevated in pancreatic carcinoma.

The deduced 416-amino acid preproenzyme (EC 3.4.17.2) has a 15-amino acid signal peptide and a 95-amino acid activation peptide. It shares 76% and 84% sequence identity with the rat and bovine homologs, respectively. DNA blot analysis indicated that the PCPB mRNA is transcribed from a single locus. Northern blot analysis demonstrated pancreas-specific expression.

Reference

"Isolation of a cDNA encoding a human serum marker for acute pancreatitis. Identification of pancreas-specific protein as pancreatic procarboxypeptidase B."
J. Biol. Chem. 267:2575-2581(1992) [PubMed] [Europe PMC] [Abstract]

"Comparative analysis of the sequences and three-dimensional models of human procarboxypeptidases A1, A2 and B."
Biol. Chem. 379:149-155(1998) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and properties of five different forms of human procarboxypeptidases."
Eur. J. Biochem. 179:609-616(1989) [PubMed] [Europe PMC] [Abstract]

"Human procarboxypeptidase B: three-dimensional structure and implications for thrombin-activatable fibrinolysis inhibitor (TAFI)."
J. Mol. Biol. 321:537-547(2002) [PubMed] [Europe PMC] [Abstract]