Carboxypeptidase E (CPE)

CPH; Enkephalin Convertase; Carboxypeptidase H; Prohormone-processing carboxypeptidase

SPN	R476
HGNC	2303
MGI	101932
PubMed	2897826
RGD	2394
UniProt	P16870
Wiki	CPE

Carboxypeptidase E cleaves C-terminal amino acid residues and is involved in neuropeptide processing. It is a peripheral membrane protein. CPE specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Carboxypeptidase E is found in neuroendocrine cells and in adrenal gland chromaffin cells. The glycoprotein can be both membrane-associated or soluble. At the C-end of the molecule lies an amphiphilic α-helix which might be responsible for the membrane localisation. Carboxypeptidase E is found in all species of vertebrates that have been examined, and is also present in many other organisms that have been studied . Interesting, carboxypeptidase E is not found in the fruit fly, and another enzyme fills in for carboxypeptidase E in this organism.

Reference

"Human carboxypeptidase E. Isolation and characterization of the cDNA, sequence conservation, expression and processing in vitro."
Biochem. J. 267:517-525(1990) [PubMed] [Europe PMC] [Abstract]

"Organization of the human carboxypeptidase E gene and molecular scanning for mutations in Japanese subjects with NIDDM or obesity."
Diabetologia 41:701-705(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers."
J. Clin. Invest. 121:880-892(2011) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]