Carboxypeptidase N1 (CPN1)
CPN; SCPN; ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator.
This enzyme is a tetramer composed of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency.The predicted protein is 458 amino acids long. Carboxypeptidase N is a 280-kD tetrameric complex consisting of 2 identical 83-kD regulatory subunits and 2 identical 50-kD catalytic subunits.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Hu01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Hu01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Hu01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Hu01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Hu01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Mu01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Mu01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Mu01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Mu01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Mu01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Ra01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Ra01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Ra01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Ra01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Ra01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Ca01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Ca01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Ca01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Ca01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Ca01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Po01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Po01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Po01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Po01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Po01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Bo01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Bo01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Bo01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Bo01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Bo01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Rb01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Rb01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Rb01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Rb01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Rb01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR475Mo01 | Recombinant Carboxypeptidase N1 (CPN1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR475Mo01 | Monoclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IP. |
| PAR475Mo01 | Polyclonal Antibody to Carboxypeptidase N1 (CPN1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR475Mo01 | CLIA Kit for Carboxypeptidase N1 (CPN1) | CLIA assay for Antigen Detection |
| ELR475Mo01 | ELISA Kit for Carboxypeptidase N1 (CPN1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1)."
Eur. J. Biochem. 178:603-607(1989) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases."
Biochem. Biophys. Res. Commun. 154:1323-1329(1988) [PubMed] [Europe PMC] [Abstract]
"On the specificity of carboxypeptidase N, a comparative study."
Biol. Chem. Hoppe-Seyler 374:843-849(1993) [PubMed] [Europe PMC] [Abstract]
"Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain."
J. Mol. Biol. 366:504-516(2007) [PubMed] [Europe PMC] [Abstract]
"DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency."
J. Hum. Genet. 48:20-22(2003) [PubMed] [Europe PMC] [Abstract]