Carboxypeptidase N2 (CPN2)

ACBP; Carboxypeptidase N 83 kDa chain; Carboxypeptidase N large subunit; Carboxypeptidase N regulatory subunit; Carboxypeptidase N polypeptide 2

SPN	R474
HGNC	2313
MGI	1919006
PubMed	19383910
RGD	1305170
UniProt	P22792
Wiki	CPN2

Carboxypeptidase N is a 280-kD tetrameric glycoprotein that is synthesized by the liver and secreted into the plasma. It consists of 2 identical 83-kD regulatory subunits and 2 identical 50-kD catalytic subunits (CPN1). Carboxypeptidase N has frequently been called serum or plasma carboxypeptidase B, which is misleading since the enzymatic and physical properties and the protein sequences of carboxypeptidase N and pancreatic carboxypeptidase B are quite distinct.

By screening a liver expression library with antibodies against carboxypeptidase N, Tan et al. (1990) isolated a cDNA encoding the 83-kD regulatory subunit, or CPN2. The predicted 536-amino acid protein contains a region of twelve 24-residue leucine-rich repeats and 5 leucine zipper motifs.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R474Hu01	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	PR474Hu01	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	KER474Hu	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	MR474Ra21	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	PR474Ra01	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	KER474Ra	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Carboxypeptidase N2 (CPN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Carboxypeptidase N2 (CPN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Carboxypeptidase N2 (CPN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Carboxypeptidase N2 (CPN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Carboxypeptidase N2 (CPN2)	CLIA assay for Antigen Detection

Reference

"The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats."
J. Biol. Chem. 265:13-19(1990) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases."
Biochem. Biophys. Res. Commun. 154:1323-1329(1988) [PubMed] [Europe PMC] [Abstract]

"Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]