Carboxypeptidase Z (CPZ)

SPN	R472
HGNC	2333
MGI	88487
PubMed	18847325
RGD	620496
UniProt	Q66K79
Wiki	CPZ

Carboxypeptidase Z is a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms.

The 390-residue carboxypeptidase domain of CPZ shares 49% amino acid identity with CPE and CPN1 and is followed by a unique C-terminal region. When expressed in a baculovirus system, CPZ displayed carboxypeptidase activity towards substrates with C-terminal basic residues. On Western blots, CPZ migrated as a 71-kD protein.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Hu01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Hu01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Hu01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Hu01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Hu01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Mu01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Mu01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Mu01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Mu01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Mu01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Ra01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Ra01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Ra01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Ra01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Ra01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Ca01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Ca01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Ca01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Ca01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Ca01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Po01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Po01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Po01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Po01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Po01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Bo01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Bo01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Bo01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Bo01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Bo01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Rb01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Rb01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Rb01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Rb01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Rb01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR472Mo01	Recombinant Carboxypeptidase Z (CPZ)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR472Mo01	Monoclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IP.
Antibodies	PAR472Mo01	Polyclonal Antibody to Carboxypeptidase Z (CPZ)	WB; IHC; ICC; IF.
Assay Kits	CLR472Mo01	CLIA Kit for Carboxypeptidase Z (CPZ)	CLIA assay for Antigen Detection
Assay Kits	ELR472Mo01	ELISA Kit for Carboxypeptidase Z (CPZ)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Cloning and expression of human carboxypeptidase Z, a novel metallocarboxypeptidase."
J. Biol. Chem. 272:10543-10550(1997) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and characterization of human metallocarboxypeptidase Z."
Biochem. Biophys. Res. Commun. 256:564-568(1999) [PubMed] [Europe PMC] [Abstract]

"Carboxypeptidase Z is present in the regulated secretory pathway and extracellular matrix in cultured cells and in human tissues."
J. Biol. Chem. 275:4865-4870(2000) [PubMed] [Europe PMC] [Abstract]

"Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding."
Cell. Mol. Life Sci. 58:1790-1804(2001) [PubMed] [Europe PMC] [Abstract]

"Immunohistochemical localization of carboxypeptidases D, E, and Z in pituitary adenomas and normal human pituitary."
J. Histochem. Cytochem. 50:1509-1516(2002) [PubMed] [Europe PMC] [Abstract]