Crystallin Beta A1 (CRYbA1)

CRYB1; Eye Lens Structural Protein

SPN	R456
HGNC	2394
MGI	88518
PubMed	15016766
RGD	2415
UniProt	P05813
Wiki	CRYBA1

Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins.

CRYbA1, a beta acidic group member, encodes two proteins (crystallin, beta A3 and crystallin, beta A1) from a single mRNA, the latter protein is 17 aa shorter than crystallin, beta A3 and is generated by use of an alternate translation initiation site. Deletion of exons 3 and 4 causes the autosomal dominant disease 'zonular cataract with sutural opacities'.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R456Mu01	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	PR456Mu01	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	KER456Mu	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Crystallin Beta A1 (CRYbA1)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Crystallin Beta A1 (CRYbA1)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Crystallin Beta A1 (CRYbA1)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Crystallin Beta A1 (CRYbA1)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Crystallin Beta A1 (CRYbA1)	CLIA assay for Antigen Detection

Reference

"Characterization of the human beta-crystallin gene Hu beta A3/A1 reveals ancestral relationships among the beta gamma-crystallin superfamily."
J. Biol. Chem. 261:12420-12427(1986) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Sequence analysis of betaA3, betaB3, and betaA4 crystallins completes the identification of the major proteins in young human lens."
J. Biol. Chem. 272:2268-2275(1997) [PubMed] [Europe PMC] [Abstract]

"Autosomal dominant zonular cataract with sutural opacities is associated with a splice mutation in the betaA3/A1-crystallin gene."
Mol. Vis. 4:21-21(1998) [PubMed] [Europe PMC] [Abstract]

"Characterization of the G91del CRYBA1/3-crystallin protein: a cause of human inherited cataract."
Hum. Mol. Genet. 13:945-953(2004) [PubMed] [Europe PMC] [Abstract]

"Modifications of human betaA1/betaA3-crystallins include S-methylation, glutathiolation, and truncation."
Protein Sci. 14:45-54(2005) [PubMed] [Europe PMC] [Abstract]