Endoplasmic Reticulum Protein 44 (ERP44)

TXNDC4; PDIA10; Thioredoxin Domain Containing 4; Protein Disulfide Isomerase Family A,Member 10

SPN	R393
HGNC	18311
MGI	1923549
PubMed	11847130
RGD	1309176
UniProt	Q9BS26
Wiki	ERP44

The transcript contains a repetitive element in the 3-prime UTR, and the deduced 451-amino acid protein has an apparent molecular mass of 50 kD, as estimated by SDS-PAGE. KIAA0573 shares weak homology with barley protein disulfide isomerase precursor. RT-PCR detected robust expression in all tissues examined.

ERp44, deduced 436-amino acid protein has an N-terminal endoplasmic reticulum (ER) targeting signal sequence. After cleavage, the calculated molecular mass of ERp44 is 43.9 kD. ERp44 also contains a thioredoxin-like domain, which includes a CRFS motif; a calsequestrin -like domain; and a C-terminal ER retention signal (RDEL). The CRFS motif is present in mouse, fly, and nematode ERp44 homologs.

Reference

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EMBO J. 21:835-844(2002) [PubMed] [Europe PMC] [Abstract]

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Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Thiol-mediated protein retention in the endoplasmic reticulum: the role of ERp44."
EMBO J. 22:5015-5022(2003) [PubMed] [Europe PMC] [Abstract]

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Proteomics 2:288-305(2002) [PubMed] [Europe PMC] [Abstract]

"Subtype-specific and ER lumenal environment-dependent regulation of inositol 1,4,5-trisphosphate receptor type 1 by ERp44."
Cell 120:85-98(2005) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of human ERp44 shows a dynamic functional modulation by its carboxy-terminal tail."
EMBO Rep. 9:642-647(2008) [PubMed] [Europe PMC] [Abstract]