Endothelin Converting Enzyme 2 (ECE2)

Methyltransferase-like region

SPN	R383
HGNC	13275
MGI	1101356
RGD	1303039
UniProt	O60344

Endothelin-converting enzymes, such as ECE2 are type II metalloproteases that generate functionally pleiotropic members of the endothelin vasoactive peptide family.The deduced protein contains 765 amino acids. ECE2 had an apparent molecular mass of 81 kD by SDS-PAGE.The ECE2A variant contains exons 1A and 2A and encodes a deduced 787-amino acid protein with a calculated molecular mass of 89.1 kD. ECE2A has an intracytoplasmic tail, a transmembrane domain, and a large extracellular catalytic domain with a zinc-binding motif conserved in Zn(2+) metalloproteases. It has 9 N-glycosylation sites. The ECE2B variant contains exons 1B and 2B and encodes a deduced 682-amino acid protein with a calculated molecular mass of 86.4 kD. ECE2B differs from ECE2A only in the intracytoplasmic tail.

Reference

"Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization."
Biochim. Biophys. Acta 1522:46-52(2001) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of endothelin-converting enzyme-2. Implication for a role in the nonclassical processing of regulatory peptides."
J. Biol. Chem. 278:14704-14711(2003) [PubMed] [Europe PMC] [Abstract]

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

"Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues."
Exp. Cell Res. 313:450-461(2007) [PubMed] [Europe PMC] [Abstract]

"An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene."
Proteins 74:789-793(2009) [PubMed] [Europe PMC] [Abstract]