Endothelin 2 (EDN2)

ET2; PPET2; Preproendothelin-2

SPN	R382
HGNC	3177
MGI	95284
PubMed	18516093
RGD	2533
UniProt	P20800
Wiki	Endothelin_2

Endothelin 2 is a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation.
The human endothelins represent a gene family comprised of endothelin-1, endothelin-2, and endothelin-3 . Based on the deduced amino acid sequences of the cloned ET2 and ET3 genes, corresponding proteins have been chemically synthesized and their vasoconstrictor activities studied. Of the 3 isopeptides, ET-2 has the most potent vasoconstrictor activity.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R382Hu01	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	MR382Hu21	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	PR382Hu01	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R382Ra01	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	MR382Ra21	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	PR382Ra01	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Endothelin 2 (EDN2)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Endothelin 2 (EDN2)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Endothelin 2 (EDN2)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Endothelin 2 (EDN2)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Endothelin 2 (EDN2)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Endothelin 2 (EDN2)	CLIA assay for Antigen Detection

Reference

"Specific expression of human endothelin-2 (ET-2) gene in a renal adenocarcinoma cell line. Molecular cloning of cDNA encoding the precursor of ET-2 and its characterization."
FEBS Lett. 274:136-140(1990) [PubMed] [Europe PMC] [Abstract]

"cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2."
Genomics 10:236-242(1991) [PubMed] [Europe PMC] [Abstract]

"Expression of endothelin-2 (ET-2) gene in a human renal adenocarcinoma cell line: purification and cDNA cloning of ET-2."
J. Cardiovasc. Pharmacol. 17:S39-S43(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes."
Proc. Natl. Acad. Sci. U.S.A. 86:2863-2867(1989) [PubMed] [Europe PMC] [Abstract]

"Proteolytic processing of big endothelin-3 by the kell blood group protein."
Blood 94:1440-1450(1999) [PubMed] [Europe PMC] [Abstract]

"Endothelin-1 and ETA receptor expression in vascular smooth muscle cells from human placenta: a new ETA receptor messenger ribonucleic acid is generated by alternative splicing of exon 3."
J. Clin. Endocrinol. Metab. 82:3116-3123(1997) [PubMed] [Europe PMC] [Abstract]