Fibronectin Leucine Rich Transmembrane Protein 1 (FLRT1)

Fibronectin-like domain-containing leucine-rich transmembrane protein 1; Leucine-rich repeat transmembrane protein FLRT1

SPN	R343
HGNC	3760
MGI	3026647
PubMed	10644439
RGD	1565152
UniProt	Q9NZU1

FLRT1 shares 55% amino acid sequence identity with FLRT3 and 41% identity with FLRT2. Recombinant FLRT1 expressed in SF9 insect cells and monkey COS-1 cells migrated as a 90-kD protein on SDS-polyacrylamide gels. The authors demonstrated that FLRT1 is glycosylated.

Northern blot analysis of a variety of human adult and fetal tissues detected a major 4.4-kb FLRT1 transcript only in adult and fetal brain and kidney. Within adult brain, FLRT1 expression was found in all subregions examined, namely putamen, temporal lobe, frontal lobe, occipital lobe, medulla, cortex, cerebellum, and spinal cord; besides the 4.4-kb transcript, an additional 6-kb FLRT1 transcript was present in all subregions except cerebellum.

Reference

"Identification of FLRT1, FLRT2, and FLRT3: a novel family of transmembrane leucine-rich repeat proteins."
Genomics 62:417-426(1999) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]