Folate Receptor 1, Adult (FOLR1)

FBP; FOLR; FR-alpha; MOv18; Adult folate-binding protein; KB cells FBP; Ovarian tumor-associated antigen MOv18

SPN	R337
HGNC	3791
MGI	95568
PubMed	1717147
RGD	71032
UniProt	P15328
Wiki	FOLR1

Folate receptor alpha is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence.Exclusively expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum.

Reference

"Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells."
J. Biol. Chem. 264:14893-14901(1989) [PubMed] [Europe PMC] [Abstract]

"Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol."
J. Clin. Invest. 84:715-720(1989) [PubMed] [Europe PMC] [Abstract]

"Folate-binding protein is a marker for ovarian cancer."
Cancer Res. 51:5329-5338(1991) [PubMed] [Europe PMC] [Abstract]

"Cloning of a tumor-associated antigen: MOv18 and MOv19 antibodies recognize a folate-binding protein."
Cancer Res. 51:6125-6132(1991) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the gene and a related pseudogene for a human folate binding protein."
Biochim. Biophys. Acta 1131:91-94(1992) [PubMed] [Europe PMC] [Abstract]

"The divergent 5' termini of the alpha human folate receptor (hFR) mRNAs originate from two tissue-specific promoters and alternative splicing: characterization of the alpha hFR gene structure."
Biochemistry 36:1467-1478(1997) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA."
J. Biol. Chem. 264:5806-5811(1989) [PubMed] [Europe PMC] [Abstract]

"Purified membrane and soluble folate binding proteins from cultured KB cells have similar amino acid compositions and molecular weights but differ in fatty acid acylation."
Proc. Natl. Acad. Sci. U.S.A. 84:6546-6549(1987) [PubMed] [Europe PMC] [Abstract]

"UMSCC38 cells amplified at 11q13 for the folate receptor synthesize a mutant nonfunctional folate receptor."
Cancer Res. 54:3905-3911(1994) [PubMed] [Europe PMC] [Abstract]

"Preferred sites of glycosylphosphatidylinositol modification in folate receptors and constraints in the primary structure of the hydrophobic portion of the signal."
Biochemistry 34:14594-14600(1995) [PubMed] [Europe PMC] [Abstract]

"Endocytosis of GPI-linked membrane folate receptor-alpha."
J. Cell Biol. 132:35-47(1996) [PubMed] [Europe PMC] [Abstract]

"Proteomic analysis of glycosylphosphatidylinositol-anchored membrane proteins."
Mol. Cell. Proteomics 2:1261-1270(2003) [PubMed] [Europe PMC] [Abstract]

"Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment."
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"Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments."
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"Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]

"Folate receptor alpha defect causes cerebral folate transport deficiency: a treatable neurodegenerative disorder associated with disturbed myelin metabolism."
Am. J. Hum. Genet. 85:354-363(2009) [PubMed] [Europe PMC] [Abstract]

"Structural basis for molecular recognition of folic acid by folate receptors."
Nature 500:486-489(2013) [PubMed] [Europe PMC] [Abstract]

"Structures of human folate receptors reveal biological trafficking states and diversity in folate and antifolate recognition."
Proc. Natl. Acad. Sci. U.S.A. 110:15180-15188(2013) [PubMed] [Europe PMC] [Abstract]