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Growth Factor Receptor Bound Protein 10 (Grb10)

GRB-IR; IRBP; MEG1; RSS; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR

Growth factor receptor-bound protein 10 is a protein belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner. GRB10 gene is alternatively spliced, producing transcripts that encode proteins either with or without a 46-amino acid stretch that contains part of the PH domain. The SH2 and PH domains of the human GRB10 protein are 99% and 84% identical, respectively, to those of mouse Grb10.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins R329Hu01 Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies MR329Hu21 Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
PR329Hu01 Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits KER329Hu ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
KCR329Hu CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Growth Factor Receptor Bound Protein 10 (Grb10) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Growth Factor Receptor Bound Protein 10 (Grb10) Bioactivity
Antibodies NONE Monoclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Growth Factor Receptor Bound Protein 10 (Grb10) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Growth Factor Receptor Bound Protein 10 (Grb10) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Growth Factor Receptor Bound Protein 10 (Grb10) CLIA assay for Antigen Detection

Reference

"Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function."
Proc. Natl. Acad. Sci. U.S.A. 92:10287-10291(1995) [PubMed] [Europe PMC] [Abstract]

"Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling."
J. Biol. Chem. 271:22506-22513(1996) [PubMed] [Europe PMC] [Abstract]

"Human GRB-IR-beta/GRB10: splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains."
J. Biol. Chem. 272:2659-2667(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma."
J. Biol. Chem. 272:29104-29112(1997) [PubMed] [Europe PMC] [Abstract]

"Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases."
J. Biol. Chem. 273:10475-10484(1998) [PubMed] [Europe PMC] [Abstract]

"Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase."
Genes Cells 3:431-441(1998) [PubMed] [Europe PMC] [Abstract]

"Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease."
Oncogene 17:3065-3070(1998) [PubMed] [Europe PMC] [Abstract]

"Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion."
Hum. Mol. Genet. 9:1587-1595(2000) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of human chromosome 7."
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]

"Human chromosome 7: DNA sequence and biology."
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of Grb10 by mitogen-activated protein kinase: identification of Ser150 and Ser476 of human Grb10zeta as major phosphorylation sites."
Biochemistry 44:8890-8897(2005) [PubMed] [Europe PMC] [Abstract]

"Evidence against GRB10 as the gene responsible for Silver-Russell syndrome."
Biochem. Biophys. Res. Commun. 286:943-948(2001) [PubMed] [Europe PMC] [Abstract]

"Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor."
J. Biol. Chem. 278:8460-8467(2003) [PubMed] [Europe PMC] [Abstract]

"NIK is a component of the EGF/heregulin receptor signaling complexes."
Oncogene 22:4348-4355(2003) [PubMed] [Europe PMC] [Abstract]

"Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation."
J. Biol. Chem. 279:26754-26761(2004) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation of grb10 regulates its interaction with 14-3-3."
J. Biol. Chem. 280:16987-16993(2005) [PubMed] [Europe PMC] [Abstract]

"Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation."
Am. J. Physiol. 290:E1262-E1266(2006) [PubMed] [Europe PMC] [Abstract]

"GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway."
Biochem. Biophys. Res. Commun. 356:648-654(2007) [PubMed] [Europe PMC] [Abstract]

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression."
Hum. Mol. Genet. 18:3066-3074(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling."
Science 332:1317-1322(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis for dimerization of the Grb10 Src homology 2 domain. Implications for ligand specificity."
J. Biol. Chem. 278:13257-13264(2003) [PubMed] [Europe PMC] [Abstract]

"Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14."
Nat. Struct. Mol. Biol. 16:833-839(2009) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Struct. Mol. Biol. 16:1331-1331(2009)

"Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome."
Am. J. Hum. Genet. 67:476-482(2000) [PubMed] [Europe PMC] [Abstract]