Growth Factor Receptor Bound Protein 14 (Grb14)

GRB14 adapter protein

SPN	R328
HGNC	4565
MGI	1355324
PubMed	8647858
RGD	61869
UniProt	Q14449
Wiki	GRB14

Growth factor receptor-bound protein 14 is a protein belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors.

This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Transcript variants have been reported for this gene, but their full-length natures have not been determined to date.Expressed at high levels in the liver, kidney, pancreas, testis, ovary, heart and skeletal muscle.

Reference

"Cloning and characterization of GRB14, a novel member of the GRB7 gene family."
J. Biol. Chem. 271:12502-12510(1996) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14."
J. Biol. Chem. 277:4845-4852(2002) [PubMed] [Europe PMC] [Abstract]

"The adaptor protein Grb14 regulates the localization of 3-phosphoinositide-dependent kinase-1."
J. Biol. Chem. 279:37518-37527(2004) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14."
Nat. Struct. Mol. Biol. 16:833-839(2009) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Struct. Mol. Biol. 16:1331-1331(2009)

"Tyrosine phosphorylation of Grb14 by Tie2."
Cell Commun. Signal. 8:30-30(2010) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14."
Mol. Cell 20:325-333(2005) [PubMed] [Europe PMC] [Abstract]

"Resequencing of 29 candidate genes in patients with familial and sporadic amyotrophic lateral sclerosis."
Arch. Neurol. 68:587-593(2011) [PubMed] [Europe PMC] [Abstract]