Heart And Neural Crest Derivatives Expressed Protein 2 (HAND2)

Thing2; dHand; Hed; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2

SPN	R326
HGNC	4808
MGI	103580
PubMed	9878849
RGD	621207
UniProt	P61296
Wiki	HAND2

Heart- and neural crest derivatives-expressed protein 2 is a protein belongs to the basic helix-loop-helix family of transcription factors.

This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.

Reference

"Molecular cloning of the human HAND2 gene."
Biochim. Biophys. Acta 1443:393-399(1998) [PubMed] [Europe PMC] [Abstract]

"Co-regulated expression of HAND2 and DEIN by a bidirectional promoter with asymmetrical activity in neuroblastoma."
BMC Mol. Biol. 10:28-28(2009) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]