Junctophilin 3 (JPH3)

CAGL237; HDL2; JP-3; JP3; TNRC22; Trinucleotide Repeat Containing 22

SPN	R308
HGNC	14203
MGI	1891497
PubMed	21555070
RGD	1308416
UniProt	Q8WXH2
Wiki	JPH3

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels.

Junctophilin-3 is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansions at the Huntington's disease (HD)-like 2 locus have been identified in this gene, which is a member of the junctophilin gene family.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R308Hu01	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R308Mu01	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Junctophilin 3 (JPH3)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Junctophilin 3 (JPH3)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Junctophilin 3 (JPH3)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Junctophilin 3 (JPH3)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Junctophilin 3 (JPH3)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Junctophilin 3 (JPH3)	CLIA assay for Antigen Detection

Reference

"Characterization of human junctophilin subtype genes."
Biochem. Biophys. Res. Commun. 273:920-927(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A repeat expansion in the gene encoding junctophilin-3 is associated with Huntington disease-like 2."
Nat. Genet. 29:377-378(2001) [PubMed] [Europe PMC] [Abstract]

"CAG/CTG repeat expansions at the Huntington's disease-like 2 locus are rare in Huntington's disease patients."
Neurology 58:965-967(2002) [PubMed] [Europe PMC] [Abstract]

"Huntington's disease-like 2 can present as chorea-acanthocytosis."
Neurology 61:1002-1004(2003) [PubMed] [Europe PMC] [Abstract]