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Kinesin Family, Member 18A (KIF18A)
Kinesin Family, Member 18A (KIF18A)
MS-KIF18A; Marrow stromal KIF18A; Kinesin-like protein KIF18A
KIF18A contains a motor domain and conserved ATP- and microtubule-binding sites, and the central region is predicted to have an alpha-helical coiled-coil, followed by a C-terminal cargo-binding domain. Nuclear localization signals, protein-protein interaction motifs such as SH3, WW, AP-1, and FHA domains, and potential sites for phosphorylation and sumoylation were also identified. KIF18A shares 84% and 81% homology with the mouse and rat homologs, respectively. Indirect immunofluorescence microscopy localized endogenous KIF18A to the nucleus, cytoplasm, and plasma membrane ruffles in preosteogenic marrow stromal cells. Punctate cytoplasmic staining of KIF18A was associated with microtubules and partial colocalization with actin.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
R279Hu01
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
MR279Hu21
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
PR279Hu01
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
KER279Hu
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Kinesin Family, Member 18A (KIF18A) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Kinesin Family, Member 18A (KIF18A) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Kinesin Family, Member 18A (KIF18A) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Kinesin Family, Member 18A (KIF18A) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Kinesin Family, Member 18A (KIF18A) CLIA assay for Antigen Detection
Reference
"MS-KIF18A, new kinesin; structure and cellular expression." Gene 351:19-28(2005) [PubMed ] [Europe PMC ] [Abstract ]
"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression." Curr. Biol. 17:488-498(2007) [PubMed ] [Europe PMC ] [Abstract ]
"MS-KIF18A, a kinesin, is associated with estrogen receptor." J. Cell. Biochem. 100:693-702(2007) [PubMed ] [Europe PMC ] [Abstract ]
"The kinesin-8 motor Kif18A suppresses kinetochore movements to control mitotic chromosome alignment." Dev. Cell 14:252-262(2008) [PubMed ] [Europe PMC ] [Abstract ]
"New insights on cellular distribution, microtubule interactions and post-translational modifications of MS-KIF18A." J. Cell. Physiol. 217:618-625(2008) [PubMed ] [Europe PMC ] [Abstract ]
"A quantitative atlas of mitotic phosphorylation." Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed ] [Europe PMC ] [Abstract ]
"Kinesin-8 molecular motors: putting the brakes on chromosome oscillations." Trends Cell Biol. 18:307-310(2008) [PubMed ] [Europe PMC ] [Abstract ]
"Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E." Cell Cycle 8:2643-2649(2009) [PubMed ] [Europe PMC ] [Abstract ]
"The regulation of MS-KIF18A expression and cross talk with estrogen receptor." PLoS ONE 4:E6407-E6407(2009) [PubMed ] [Europe PMC ] [Abstract ]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Sci. Signal. 3:RA3-RA3(2010) [PubMed ] [Europe PMC ] [Abstract ]