Leukocyte Cell Derived Chemotaxin 2 (LECT2)

Chm-II; Chm2

SPN	R256
HGNC	6550
MGI	1278342
PubMed	21394108
RGD	1305404
UniProt	O14960
Wiki	LECT2

Leukocyte cell-derived chemotaxin-2 is a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. Neutrophils migrate in response to increasing concentrations of chemotactic factors released from inflammatory sites. From the culture fluid of a human T-cell leukemia cell line (SKW-3), Yamagoe et al. (1996) isolated a 16-kD secreted protein with neutrophil chemotactic activity and designated it LECT2. They purified the protein and determined the amino acid sequence.

Reference

"Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver."
Biochim. Biophys. Acta 1396:105-113(1998) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene."
Genomics 48:324-329(1998) [PubMed] [Europe PMC] [Abstract]

"Systemic expression of a newly recognized protein, LECT2, in the human body."
Pathol. Int. 48:882-886(1998) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 5."
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2."
Immunol. Lett. 52:9-13(1996) [PubMed] [Europe PMC] [Abstract]

"Identification and assignment of three disulfide bonds in mammalian leukocyte cell-derived chemotaxin 2 by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry."
Biosci. Trends 3:139-143(2009) [PubMed] [Europe PMC] [Abstract]