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Xylosyltransferase I (XYLT1)
Xylosyltransferase I (XYLT1)
XT-I; XT1; PXYLT1; Protein O Xylosyltransferase 1
Xylosyltransferase (XT; EC 2.4.2.26) catalyzes the transfer of UDP-xylose to serine residues within XT recognition sequences of target proteins. A stable secondary structure assumed by XT1 mRNA prevented reverse transcription of the 5-prime untranslated region. The authors determined that the XT1 protein contains at least 827 amino acids and has a calculated molecular mass of at least 91 kD. It has 3 potential N-glycosylation sites and a DxD motif essential for binding nucleotide sugars in glycosyltransferases. Alignment of the XT1 and XT2 proteins with Xt1 and Xt2 from rat liver revealed highly conserved sequences in the central and C-terminal regions of the proteins. RT-PCR detected XT1 expression in all tissues examined, with highest levels in placenta, kidney, and pancreas, and lowest expression in skeletal muscle.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
R223Hu01
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
R223Mu01
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Xylosyltransferase I (XYLT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Xylosyltransferase I (XYLT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Xylosyltransferase I (XYLT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Xylosyltransferase I (XYLT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Xylosyltransferase I (XYLT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Xylosyltransferase I (XYLT1) CLIA assay for Antigen Detection
Reference
"Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity." Biochem. J. 386:227-236(2005) [PubMed ] [Europe PMC ] [Abstract ]
"Molecular cloning and expression of human UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase and its first isoform XT-II." J. Mol. Biol. 304:517-528(2000) [PubMed ] [Europe PMC ] [Abstract ]
"First isolation of human UDP-D-xylose: proteoglycan core protein beta-D-xylosyltransferase secreted from cultured JAR choriocarcinoma cells." J. Biol. Chem. 276:4940-4947(2001) [PubMed ] [Europe PMC ] [Abstract ]
"Serum xylosyltransferase: a new biochemical marker of the sclerotic process in systemic sclerosis." J. Invest. Dermatol. 112:919-924(1999) [PubMed ] [Europe PMC ] [Abstract ]
"Xylosyltransferase activity in seminal plasma of infertile men." Clin. Chim. Acta 317:199-202(2002) [PubMed ] [Europe PMC ] [Abstract ]
"Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity." J. Biol. Chem. 279:42566-42573(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Polymorphisms in the xylosyltransferase genes cause higher serum XT-I activity in patients with pseudoxanthoma elasticum (PXE) and are involved in a severe disease course." J. Med. Genet. 43:745-749(2006) [PubMed ] [Europe PMC ] [Abstract ]
"XYLT1 mutations in Desbuquois dysplasia type 2." Am. J. Hum. Genet. 94:405-414(2014) [PubMed ] [Europe PMC ] [Abstract ]
"The missing 'link': an autosomal recessive short stature syndrome caused by a hypofunctional XYLT1 mutation." Hum. Genet. 133:29-39(2014) [PubMed ] [Europe PMC ] [Abstract ]
