Peptidyl Arginine Deiminase Type VI (PADI6)

Peptidylarginine deiminase VI; Peptidyl arginine deiminase-like protein

SPN	R126
HGNC	20449
MGI	2655198
PubMed	15087120
RGD	1560424
UniProt	Q6TGC4

Peptidylarginine deiminases (PADs) convert arginine residues in proteins into citrullines. Peptidylarginine deiminases (PADs, EC 3.5.3.15), including PADI6, make up a family of posttranslational protein modification enzymes that convert arginine residues to citrulline residues in the presence of calcium ions.

PADI6,The deduced 694-amino acid protein has a calculated molecular mass of 77.7 kD. RT-PCR detected expression in adult human tissues, including ovary, peripheral blood leukocytes, and testis, with weaker expression in small intestine, spleen, lung, liver, and skeletal muscle. No expression was detected in other tissues examined. The order of the genes is p-telomere--PADI2--PADI1--PADI3--PADI4--PADI6. Mouse Padi6 maps to a syntenic Pad cluster on chromosome 4E1.

Reference

"cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI."
Acta Biochim. Pol. 51:1051-1058(2004) [PubMed] [Europe PMC] [Abstract]

"Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6."
Gene 330:19-27(2004) [PubMed] [Europe PMC] [Abstract]

"Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI."
J. Struct. Biol. 180:65-72(2012) [PubMed] [Europe PMC] [Abstract]