Peripherin (PRPH)

NEF4; Neurofilament 4

SPN	R071
HGNC	9461
MGI	97774
PubMed	22723690
RGD	3414
UniProt	P41219
Wiki	PRPH

Peripherin, a type III intermediate filament protein, was initially described by Portier et al. (1984) as a cytoskeletal protein present in neurons of the mammalian peripheral nervous system (hence, the name) and in cultured neuroblastoma cells.

The amino-terminal region contained potential serine phosphorylation sites. Northern blot analysis detected a corresponding mRNA in ganglia of the peripheral nervous system, including the superior cervical ganglion, ciliary ganglion, and dorsal root ganglion. In the central nervous system, expression was detected in motor nuclei of cranial nerves and ventral horn neurons. Expression was induced by nerve growth factor.

Reference

"The structure of the human peripherin gene (PRPH) and identification of potential regulatory elements."
Genomics 22:456-461(1994) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

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J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]