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Peroxiredoxin 3 (PRDX3)

MER5; AOP-1; AOP1; SP-22; Antioxidant Protein 1; Thioredoxin-dependent peroxide reductase, mitochondrial

PRDX3 encodes a protein with antioxidant function and is localized in the mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
PR070Hu01 Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
LR070Hu71 Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
PR070Mu01 Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
PR070Ra01 Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
LR070Ra71 Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
LR070Ra81 FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Peroxiredoxin 3 (PRDX3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Peroxiredoxin 3 (PRDX3) Bioactivity
Antibodies NONE Monoclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Peroxiredoxin 3 (PRDX3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Peroxiredoxin 3 (PRDX3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Peroxiredoxin 3 (PRDX3) CLIA assay for Antigen Detection

Reference

"Mammalian antioxidant protein complements alkylhydroperoxide reductase (ahpC) mutation in Escherichia coli."
Biochem. J. 307:377-381(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 10."
Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human liver protein map: a reference database established by microsequencing and gel comparison."
Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]

, Submitted (DEC-2008) to UniProtKB

"A method for detection of overoxidation of cysteines: peroxiredoxins are oxidized in vivo at the active-site cysteine during oxidative stress."
Biochem. J. 366:777-785(2002) [PubMed] [Europe PMC] [Abstract]

"Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically."
Eur. J. Biochem. 270:76-83(2003) [PubMed] [Europe PMC] [Abstract]

"Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state."
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"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."
J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death."
Hum. Mutat. 32:1390-1397(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]