Tumor Necrosis Factor Alpha Induced Protein 3 Interacting Protein 2 (TNIP2)

ABIN-2; ABIN2; FLIP1; KLIP; A20-binding inhibitor of NF-kappa-B activation 2; Fetal liver LKB1-interacting protein

SPN	R003
HGNC	19118
MGI	2386643
PubMed	15686714
RGD	1307717
UniProt	Q8NFZ5
Wiki	TNIP2

TNIP2 binds to the C-terminal zinc finger domain of A20 (TNFAIP3) and is involved in activation of the ERK MAP kinase pathway in various cell types.

By yeast 2-hybrid screening of a mouse fibrosarcoma cDNA library using A20 as bait, followed by database analysis, Van Huffel et al. (2001) identified human TNIP2, which they called ABIN2. The mouse and human proteins share 76% amino acid identity. Northern blot analysis of mouse tissues revealed ubiquitous expression, with highest expression in kidney and weakest expression in skeletal muscle. Western blot analysis revealed a 50-kD endogenous Abin2 protein in mouse macrophages and fibrosarcoma cells.

Reference

"Identification of a novel A20-binding inhibitor of nuclear factor-kappaB activation termed ABIN-2."
J. Biol. Chem. 276:30216-30223(2001) [PubMed] [Europe PMC] [Abstract]

"An LKB1-interacting protein negatively regulates TNFalpha-induced NF-kappaB activation."
J. Biomed. Sci. 10:242-252(2003) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract].

"Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions."
FEBS Lett. 498:93-97(2001) [PubMed] [Europe PMC] [Abstract]

"ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1."
Blood 102:4407-4409(2003) [PubMed] [Europe PMC] [Abstract]

"The antiinflammatory endothelial tyrosine kinase Tie2 interacts with a novel nuclear factor-kappaB inhibitor ABIN-2."
Circ. Res. 92:630-636(2003) [PubMed] [Europe PMC] [Abstract]

"The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation."
FEBS Lett. 543:55-60(2003) [PubMed] [Europe PMC] [Abstract]

"The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis."
Biochem. J. 378:867-876(2004) [PubMed] [Europe PMC] [Abstract]

"ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability."
Mol. Cell. Biol. 24:5235-5248(2004) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin binding mediates the NF-kappaB inhibitory potential of ABIN proteins."
Oncogene 27:3739-3745(2008) [PubMed] [Europe PMC] [Abstract]

"A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity."
J. Biol. Chem. 286:32277-32288(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma."
Clin. Cancer Res. 17:1440-1451(2011) [PubMed] [Europe PMC] [Abstract]