Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8)
LTRPC6; TRPP8; CMR1; Cold And Menthol Receptor 1; Long transient receptor potential channel 6; Transient receptor potential p8
TRPM8 is an ion channel, upon activation it allows the entry of Na+ (sodium) and Ca2+ (calcium) ions to the cell that leads to depolarization and the generation of an action potential. This eventually leads to the feeling of cold. The TRPM8 protein is expresed in sensory neurons, and it is activated by cold temperatures and cooling agents, such as menthol and icilin where as WS-12 and CPS-369 are the most selective agonist of TRPM8.TRPM8 is also expressed in the prostate, lungs, and bladder where its function is not very well understood.TRPM8 upregulation in bladder tissues correlates with pain in patients with painful bladder syndromes.Furthermore, TRPM8 is upregulated in many prostate cancer cell lines and Dendreon/Genentech are pursuing an agonist approach to induce apoptosis and prostate cancer cell death.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Hu01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Hu01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Hu01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Hu01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Hu01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Mu01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Mu01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Mu01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Mu01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Mu01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Ra01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Ra01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Ra01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Ra01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Ra01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Ca01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Ca01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Ca01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Ca01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Ca01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Po01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Po01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Po01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Po01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Po01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Bo01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Bo01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Bo01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Bo01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Bo01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Rb01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Rb01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Rb01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Rb01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Rb01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ968Mo01 | Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ968Mo01 | Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IP. |
| PAQ968Mo01 | Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ968Mo01 | CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | CLIA assay for Antigen Detection |
| ELQ968Mo01 | ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 8 (TRPM8) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins."
Cancer Res. 61:3760-3769(2001) [PubMed] [Europe PMC] [Abstract]
"Novel role of cold/menthol-sensitive transient receptor potential melastatine family member 8 (TRPM8) in the activation of store-operated channels in LNCaP human prostate cancer epithelial cells."
J. Biol. Chem. 280:39423-39435(2005) [PubMed] [Europe PMC] [Abstract]
"Regulation of activity of transient receptor potential melastatin 8 (TRPM8) channel by its short isoforms."
J. Biol. Chem. 287:2948-2962(2012) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Identification of an HLA-A*0201-restricted T-cell epitope derived from the prostate cancer-associated protein trp-p8."
Prostate 56:270-279(2003) [PubMed] [Europe PMC] [Abstract]
"The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels."
Nature 430:748-754(2004) [PubMed] [Europe PMC] [Abstract]
"Trafficking and assembly of the cold-sensitive TRPM8 channel."
J. Biol. Chem. 281:38396-38404(2006) [PubMed] [Europe PMC] [Abstract]
"TRP channel-associated factors are a novel protein family that regulates TRPM8 trafficking and activity."
J. Cell Biol. 208:89-107(2015) [PubMed] [Europe PMC] [Abstract]