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Sestrin 1 (SESN1)
Sestrin 1 (SESN1)
SEST1; PA26; p53-regulated protein PA26
Only the smaller transcript was transiently induced by p53 or by genotoxic agents in a p53-dependent manner in a colon carcinoma cell line. The deduced proteins, which are 99% identical to the mouse proteins, contain 551, 491, and 426 amino acids, respectively. RT-PCR analysis detected induction of T2 in response to p53 or genotoxic stress; however, T1 was not induced and T3 was only weakly induced. Western blot analysis showed induction of a predominant 55-kD T2 nuclear protein rather than the 68-kD T1 protein or the 48-kD T3 protein. Sequence analysis predicted, and EMSA and reporter analysis confirmed, that PA26 has a p53-binding site within intron 2. Serum starvation experiments suggested that PA26 may be a member of the growth arrest- and DNA damage-inducible, or GADD, gene family.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
KEQ929Hu
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
Q929Mu01
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
PQ929Mu01
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
KEQ929Mu
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Sestrin 1 (SESN1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Sestrin 1 (SESN1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Sestrin 1 (SESN1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Sestrin 1 (SESN1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Sestrin 1 (SESN1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Sestrin 1 (SESN1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Sestrin 1 (SESN1) CLIA assay for Antigen Detection
Reference
"PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes." Oncogene 18:127-137(1999) [PubMed ] [Europe PMC ] [Abstract ]
"PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse." Hum. Genet. 112:573-580(2003) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD." Science 304:596-600(2004) [PubMed ] [Europe PMC ] [Abstract ]
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Science 316:1160-1166(2007) [PubMed ] [Europe PMC ] [Abstract ]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Sci. Signal. 2:RA46-RA46(2009) [PubMed ] [Europe PMC ] [Abstract ]
