Secreted Frizzled Related Protein 4 (SFRP4)
FRP-4; FRPHE; Frizzled protein, human endometrium
Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.
Sequence analysis predicted that the 346-amino acid SFRP4 protein contains an N-terminal signal peptide, no transmembrane domain, and a hydrophilic C terminus. In situ hybridization analysis demonstrated exclusive expression in stromal and myometrial cells, particularly in endometrium and breast. Upregulated expression was detected in endometrial and breast carcinomas.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Hu01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Hu01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Hu01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Hu01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Hu01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Mu01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Mu01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Mu01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Mu01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Mu01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Ra01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Ra01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Ra01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Ra01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Ra01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Ca01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Ca01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Ca01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Ca01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Ca01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Po01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Po01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Po01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Po01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Po01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Bo01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Bo01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Bo01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Bo01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Bo01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Rb01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Rb01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Rb01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Rb01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Rb01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPQ928Mo01 | Recombinant Secreted Frizzled Related Protein 4 (SFRP4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAQ928Mo01 | Monoclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IP. |
| PAQ928Mo01 | Polyclonal Antibody to Secreted Frizzled Related Protein 4 (SFRP4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLQ928Mo01 | CLIA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | CLIA assay for Antigen Detection |
| ELQ928Mo01 | ELISA Kit for Secreted Frizzled Related Protein 4 (SFRP4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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"Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent."
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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression."
Cardiovasc. Res. 45:720-728(2000) [PubMed] [Europe PMC] [Abstract]
"Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours."
Eur. J. Gynaecol. Oncol. 30:133-141(2009) [PubMed] [Europe PMC] [Abstract]