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Frizzled Related Protein (FRZB)
Frizzled Related Protein (FRZB)
FRZB-PEN; FRZB1; SRFP3; FRP-3; SFRP3; FRE; FRITZ; FRZB-1; FZRB; hFIZ; Secreted frizzled-related protein 3
Frzb is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. This protein is expressed in chondrocytes making it important in skeletal development in the embryo and fetus. Frzb is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling. The CRD is highly conserved in diverse proteins, such as receptor tyrosine kinases and functions as a ligand binding domain. The C-terminal is a carboxyl terminus located intracellularly and is required for canonical signaling.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
Q925Hu01
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
MQ925Hu21
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
PQ925Hu01
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Frizzled Related Protein (FRZB) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Frizzled Related Protein (FRZB) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Frizzled Related Protein (FRZB) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Frizzled Related Protein (FRZB) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Frizzled Related Protein (FRZB) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Frizzled Related Protein (FRZB) CLIA assay for Antigen Detection
Reference
"Primary structure and tissue distribution of FRZB, a novel protein related to Drosophila frizzled, suggest a role in skeletal morphogenesis." J. Biol. Chem. 271:26131-26137(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Fritz: a secreted frizzled-related protein that inhibits Wnt activity." Mech. Dev. 63:109-125(1997) [PubMed ] [Europe PMC ] [Abstract ]
"Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer." Cell 88:747-756(1997) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Signal peptide prediction based on analysis of experimentally verified cleavage sites." Protein Sci. 13:2819-2824(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Myocilin is a modulator of Wnt signaling." Mol. Cell. Biol. 29:2139-2154(2009) [PubMed ] [Europe PMC ] [Abstract ]
"Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females." Proc. Natl. Acad. Sci. U.S.A. 101:9757-9762(2004) [PubMed ] [Europe PMC ] [Abstract ]
