Sperm Associated Antigen 9 (SPAG9)

HSS; PIG6; HLC4; JLP; PHET; C-Jun-Amino-Terminal Kinase-Interacting Protein 4; Lung Cancer Oncogene 4; Proliferation-Inducing Gene 6; Cancer/Testis Antigen 89

SPN	Q899
HGNC	14524
MGI	1918084
PubMed	9480848
RGD	1311289
UniProt	O60271
Wiki	SPAG9

Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur.

Sperm Associated Antigen 9 is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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