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Nesprin 2 (Nesp2)

SYNE2; NUA; NUANCE; SYNE-2; Synaptic nuclear envelope protein 2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein

SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. SYNE2 contains multiple spectrin repeats and a 60-amino acid C-terminal region homologous to the Drosophila protein Klarsicht. RT-PCR analysis showed low to moderate expression of 2 SYNE2 splice variants in most tissues examined, including skeletal and cardiac muscle, kidney, liver, pancreas, and placenta, and indicated that alternative splicing patterns are conserved between SYNE1 and SYNE2.Nesprin-2-gamma also has a bipartite nuclear localization signal and a leucine zipper motif.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Hu01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Hu01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Hu01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Hu01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Hu01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Mu01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Mu01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Mu01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Mu01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Mu01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Ra01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Ra01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Ra01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Ra01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Ra01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Ca01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Ca01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Ca01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Ca01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Ca01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Po01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Po01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Po01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Po01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Po01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Bo01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Bo01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Bo01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Bo01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Bo01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Rb01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Rb01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Rb01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Rb01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Rb01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPQ853Mo01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAQ853Mo01 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
PAQ853Mo01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IF.
Assay Kits CLQ853Mo01 CLIA Kit for Nesprin 2 (Nesp2) CLIA assay for Antigen Detection
ELQ853Mo01 ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection

Reference

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J. Cell Sci. 114:4485-4498(2001) [PubMed] [Europe PMC] [Abstract]

"The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."
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Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract]

"Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle."
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"Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins."
PLoS ONE 8:E63633-E63633(2013) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Nesprins: tissue-specific expression of epsilon and other short isoforms."
PLoS ONE 9:E94380-E94380(2014) [PubMed] [Europe PMC] [Abstract]

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"Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity."
Hum. Mol. Genet. 16:2816-2833(2007) [PubMed] [Europe PMC] [Abstract]