Nischarin (NISCH)

IRAS; Imidazoline Receptor Candidate; I-1 Receptor Candidate Protein; Imidazoline Receptor Antisera Selected; Imidazoline receptor antisera-selected protein

SPN	Q832
HGNC	18006
MGI	1928323
PubMed	11121431
RGD	1306950
UniProt	Q9Y2I1
Wiki	NISCH

Nischarin acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling. Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration. Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension. Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons. Acts as a modulator of Rac-regulated signal transduction pathways. Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity.

Reference

"Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization."
DNA Cell Biol. 19:319-329(2000) [PubMed] [Europe PMC] [Abstract]

"IRAS splice variants."
Ann. N. Y. Acad. Sci. 1009:419-426(2003) [PubMed] [Europe PMC] [Abstract]

"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of a partial cDNA clone detected by imidazoline receptor-selective antisera."
J. Auton. Nerv. Syst. 72:98-110(1998) [PubMed] [Europe PMC] [Abstract]

"Insulin receptor substrate 4 associates with the protein IRAS."
J. Biol. Chem. 277:19439-19447(2002) [PubMed] [Europe PMC] [Abstract]

"IRAS is an anti-apoptotic protein."
Ann. N. Y. Acad. Sci. 1009:400-412(2003) [PubMed] [Europe PMC] [Abstract]

"IRAS, the human homologue of Nischarin, prolongs survival of transfected PC12 cells."
Cell Death Differ. 10:933-935(2003) [PubMed] [Europe PMC] [Abstract]

"Human Nischarin/imidazoline receptor antisera-selected protein is targeted to the endosomes by a combined action of a PX domain and a coiled-coil region."
J. Biol. Chem. 279:54770-54782(2004) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Integrin-binding protein nischarin interacts with tumor suppressor liver kinase B1 (LKB1) to regulate cell migration of breast epithelial cells."
J. Biol. Chem. 288:15495-15509(2013) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of nischarin PX-domain."
Submitted (OCT-2010) to the PDB data bank