Free Fatty Acid Receptor 3 (FFAR3)

FFA3R; GPR41; G Protein-Coupled Receptor 41

SPN	Q831
HGNC	4499
MGI	2685324
PubMed	24325907
RGD	1311035
UniProt	O14843
Wiki	FFA3

The physiologic responses to galanin (GAL) are mediated through specific membrane receptors called GALRs, which are members of the G protein-coupled receptor (GPCR) family. Sawzdargo et al. (1997) amplified human genomic DNA using PCR with degenerate primers based on conserved sequences of human and rat GALR1 and rat Galr2 .

The GPR41 gene has no introns. GPR41 encodes a predicted 346-amino acid GPCR containing 7 transmembrane domains, 1 glycosylation site, 1 PKC phosphorylation site, 2 PKA/PKC phosphorylation sites, and 1 palmitoylation site, which is located in the C-terminal domain. The GPR41 protein shares 98% amino acid identity with GPR42 but little similarity with GALRs.

Reference

"A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1."
Biochem. Biophys. Res. Commun. 239:543-547(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids."
J. Biol. Chem. 278:11312-11319(2003) [PubMed] [Europe PMC] [Abstract]

"Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation."
J. Biol. Chem. 278:25481-25489(2003) [PubMed] [Europe PMC] [Abstract]

"Conserved polar residues in transmembrane domains V, VI, and VII of free fatty acid receptor 2 and free fatty acid receptor 3 are required for the binding and function of short chain fatty acids."
J. Biol. Chem. 283:32913-32924(2008) [PubMed] [Europe PMC] [Abstract]

"Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42."
DNA Cell Biol. 28:555-560(2009) [PubMed] [Europe PMC] [Abstract]

"Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)."
Proc. Natl. Acad. Sci. U.S.A. 108:8030-8035(2011) [PubMed] [Europe PMC] [Abstract]

"Extracellular ionic locks determine variation in constitutive activity and ligand potency between species orthologs of the free fatty acid receptors FFA2 and FFA3."
J. Biol. Chem. 287:41195-41209(2012) [PubMed] [Europe PMC] [Abstract]