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Dual Specificity Phosphatase 3 (DUSP3)

VHR; Vaccinia Virus Phosphatase VH1-Related; Dual specificity protein phosphatase VHR

DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins Q830Hu01 Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies MQ830Hu22 Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
PQ830Hu01 Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
LQ830Hu71 Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies NONE Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection

Reference

"Expression cloning of a human dual-specificity phosphatase."
Proc. Natl. Acad. Sci. U.S.A. 89:12170-12174(1992) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway."
J. Biol. Chem. 274:13271-13280(1999) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the dual specificity protein phosphatase VHR."
Science 272:1328-1331(1996) [PubMed] [Europe PMC] [Abstract]

"Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase."
Biochemistry 41:3009-3017(2002) [PubMed] [Europe PMC] [Abstract]

"Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells."
J. Med. Chem. 52:6716-6723(2009) [PubMed] [Europe PMC] [Abstract]