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Dual Specificity Phosphatase 3 (DUSP3)
Dual Specificity Phosphatase 3 (DUSP3)
VHR; Vaccinia Virus Phosphatase VH1-Related; Dual specificity protein phosphatase VHR
DUSP3 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Dual Specificity Phosphatase 3 (DUSP3) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Dual Specificity Phosphatase 3 (DUSP3) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Dual Specificity Phosphatase 3 (DUSP3) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Dual Specificity Phosphatase 3 (DUSP3) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Dual Specificity Phosphatase 3 (DUSP3) CLIA assay for Antigen Detection
Reference
"Expression cloning of a human dual-specificity phosphatase." Proc. Natl. Acad. Sci. U.S.A. 89:12170-12174(1992) [PubMed ] [Europe PMC ] [Abstract ]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Nature 440:1045-1049(2006) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]
"Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway." J. Biol. Chem. 274:13271-13280(1999) [PubMed ] [Europe PMC ] [Abstract ]
"Initial characterization of the human central proteome." BMC Syst. Biol. 5:17-17(2011) [PubMed ] [Europe PMC ] [Abstract ]
"Crystal structure of the dual specificity protein phosphatase VHR." Science 272:1328-1331(1996) [PubMed ] [Europe PMC ] [Abstract ]
"Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase." Biochemistry 41:3009-3017(2002) [PubMed ] [Europe PMC ] [Abstract ]
"Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells." J. Med. Chem. 52:6716-6723(2009) [PubMed ] [Europe PMC ] [Abstract ]