Teratocarcinoma Derived Growth Factor 1 (TDGF1)

CR; CRGF; CRIPTO; Cripto-1; Epidermal growth factor-like cripto protein CR1; Cripto-1 growth factor

SPN	Q806
HGNC	11701
MGI	98658
PubMed	12073012
RGD	1594185
UniProt	P13385
Wiki	TDGF1

CRIPTO encoding a protein of 188 amino acids. The central portion of this protein shared structural similarities with the human transforming growth factor alpha and epidermal growth factor (EGF). Northern blot analysis of a wide variety of tumor and normal cell lines and tissues showed that CRIPTO transcripts are detected only in undifferentiated cells and disappear after cell differentiation induced by retinoic acid treatment.

Comparison of the human and mouse genes revealed a perfect conservation of the exon/intron structure of the region containing the EGF-like motif. In contrast, mouse exons 1 and 3 are shorter than the corresponding human exons. This difference results in a different N-terminus in the human and mouse proteins

Reference

"Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells."
EMBO J. 8:1987-1991(1989) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the CRIPTO autosomal gene and its X-linked related sequence."
Am. J. Hum. Genet. 49:555-565(1991) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells."
Mol. Cell. Biol. 22:2586-2597(2002) [PubMed] [Europe PMC] [Abstract]

"The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto."
Eur. J. Biochem. 270:3610-3618(2003) [PubMed] [Europe PMC] [Abstract]

"Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension."
Biochim. Biophys. Acta 1778:2671-2681(2008) [PubMed] [Europe PMC] [Abstract]

"CRIPTO3, a presumed pseudogene, is expressed in cancer."
Biochem. Biophys. Res. Commun. 377:215-220(2008) [PubMed] [Europe PMC] [Abstract]