Neuropeptide Y Receptor Y5 (NPY5R)

NPYR5; NPY-Y5 receptor

SPN	Q804
HGNC	7958
MGI	108082
PubMed	15090072
RGD	3199
UniProt	Q15761
Wiki	NPY5R

Gerald et al. (1996) cloned a novel Y-type receptor that they termed Y5 from rat hypothalamus and reported that it encodes a 456-amino acid protein with less than 35% overall identity to known Y-type receptors. They identified a human Y5 homolog in the GenBank database having 87% overall identity with rat Y5.

The rat and human Y5 protein sequences share 88% identity and show 30 to 33% identity to other NPY receptor subtypes. Northern blot analysis revealed that NPY5R is expressed as a 2.6-kb mRNA in the brain but in no other tissues tested. Hu et al. (1996) also isolated another rat cDNA containing a 123-amino acid insertion near the 5-prime end, which may represent an alternatively spliced form of the gene.

Reference

"Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior."
J. Biol. Chem. 271:26315-26319(1996) [PubMed] [Europe PMC] [Abstract]

"A receptor subtype involved in neuropeptide-Y-induced food intake."
Nature 382:168-171(1996) [PubMed] [Europe PMC] [Abstract]

"Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation."
Genomics 41:315-319(1997) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]