Adenosine A2a Receptor (ADORA2a)

ADORA2; RDC8; hA2AR

SPN	Q796
HGNC	263
MGI	99402
PubMed	17329997
RGD	2049
UniProt	P29274
Wiki	ADORA2a

ADORA2a is a member of the G protein-coupled receptor (GPCR) family which possess seven transmembrane alpha helices. The crystallographic structure of the adenosine A_2A receptor PDB 3EML (see figure to the right) reveals a ligand binding pocket distinct from that of other structurally determined GPCRs.

Adenosine A2a Receptoris one of several receptor subtypes for adenosine. The activity of the encoded protein, a G protein-coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine.As with the A₁, the A_2A receptors are believed to play a role in regulating myocardial oxygen consumption and coronary blood flow.

Reference

"Molecular characterization of a human brain adenosine A2 receptor."
Brain Res. Mol. Brain Res. 15:62-66(1992) [PubMed] [Europe PMC] [Abstract]

"Characterization and chromosomal localization of the human A2a adenosine receptor gene: ADORA2A."
Biochem. Biophys. Res. Commun. 223:461-467(1996) [PubMed] [Europe PMC] [Abstract]

"A genome annotation-driven approach to cloning the human ORFeome."
Genome Biol. 5:R84.1-R84.11(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The dopamine D(4) receptor, the ultimate disordered protein."
J. Recept. Signal Transduct. 30:331-336(2010) [PubMed] [Europe PMC] [Abstract]

"Site-directed mutagenesis identifies residues involved in ligand recognition in the human A2a adenosine receptor."
J. Biol. Chem. 270:13987-13997(1995) [PubMed] [Europe PMC] [Abstract]

"The ubiquitin-specific protease Usp4 regulates the cell surface level of the A2A receptor."
Mol. Pharmacol. 69:1083-1094(2006) [PubMed] [Europe PMC] [Abstract]

"The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist."
Science 322:1211-1217(2008) [PubMed] [Europe PMC] [Abstract]

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 23:373-373(1999)