Somatostatin Receptor 2 (SSTR2)

SRIF-1

SPN	Q770
HGNC	11331
MGI	98328
PubMed	22932785
RGD	3763
UniProt	P30874
Wiki	SSTR2

Somatostatin exerts its biologic effects by binding to specific high-affinity receptors, which appear in many cases to be coupled to GTP-binding proteins.the human medullary thyroid carcinoma cell line TT , expresses all SSTR subtypes; that SSTR2 activation inhibits DNA synthesis and cell proliferation, whereas SSTR5 activation increases DNA synthesis; and that an SSTR2 preferential agonist can antagonize SSTR5-selective agonist action, and vice versa. These findings suggest a tissue-specific function and a tissue-specific interaction between the 2 receptors.the prognostic information derived from SSTR2 is apparently independent from MYCN amplification, as assessed by stratifying SSTR2 values according to MYCN. The authors concluded that SSTR2 expression represents a prognostic marker for neuroblastoma.

Reference

"Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney."
Proc. Natl. Acad. Sci. U.S.A. 89:251-255(1992) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and transcriptional regulation of the human somatostatin receptor type 2."
Mol. Cell. Endocrinol. 157:75-85(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation."
Biochem. Biophys. Res. Commun. 192:288-294(1993) [PubMed] [Europe PMC] [Abstract]

"Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain."
J. Biol. Chem. 274:32997-33001(1999) [PubMed] [Europe PMC] [Abstract]

"Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking."
J. Biol. Chem. 279:36179-36183(2004) [PubMed] [Europe PMC] [Abstract]

"Cell growth inhibition and functioning of human somatostatin receptor type 2 are modulated by receptor heterodimerization."
Mol. Endocrinol. 22:2278-2292(2008) [PubMed] [Europe PMC] [Abstract]

"The somatostatin 2A receptor is enriched in migrating neurons during rat and human brain development and stimulates migration and axonal outgrowth."
PLoS ONE 4:E5509-E5509(2009) [PubMed] [Europe PMC] [Abstract]

"SSTR2 is the functionally dominant somatostatin receptor in human pancreatic beta- and alpha-cells."
Am. J. Physiol. 303:E1107-E1116(2012) [PubMed] [Europe PMC] [Abstract]

"Identification of critical residues involved in ligand binding and G protein signaling in human somatostatin receptor subtype 2."
Endocrinology 153:2747-2755(2012) [PubMed] [Europe PMC] [Abstract]